This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. Concerns about the health effects of BPA have led some manufacturers replacing it with other bisphenols, such as bisphenol S and bisphenol F. These are produced in a similar manner to BPA, by replacing acetone with other ketones, which undergo analogous condensation reactions. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. What is the formula of phenol formaldehyde resin? BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. Lactational transfer of bisphenol A in Sprague-Dawley rats. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. In recent years, many claims have been made about the health effects of BPA. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Compounds without a Phenanthrene Nucleus", "Bio-Based Aromatic Epoxy Monomers for Thermoset Materials", "European Union Summary Risk Assessment Report - Bis (2-ethylhexyl) Phthalate (DEHP)", "Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes", "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004", "The state of bisphenol research in the lesser developed countries of the EU: a mini-review", "An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment", "Bisphenol A and baby bottles: challenges and perspectives", "Consolidated federal laws of canada, Canada Consumer Product Safety Act", "MSC unanimously agrees that Bisphenol A is an endocrine disruptor - All news - ECHA", "EU court confirms BPA as substance of 'very high concern', "Estrogen biology: new insights into GPER function and clinical opportunities", "Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation", "A critical analysis of the biological impacts of plasticizers on wildlife", Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7-Methyl-19-norandrostenedione (MENT dione, trestione), 11-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethisterone), Oxabolone cipionate (oxabolone cypionate), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), 3-Methyl-19-methyleneandrosta-3,5-dien-17-ol, 10,17-Dihydroxyestra-1,4-dien-3-one (DHED), 16,17-Epiestriol (16-hydroxy-17-estradiol), 17-Epiestriol (16-hydroxy-17-estradiol), Epiestriol (16-epiestriol, 16-hydroxy-17-estradiol), Fosfestrol (diethylstilbestrol diphosphate), Furostilbestrol (diethylstilbestrol difuroate), Triphenylmethylethylene (triphenylpropene), https://en.wikipedia.org/w/index.php?title=Bisphenol_A&oldid=1134371642, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, Polycyanurates can be produced from BPA by way of its di-, Bisphenol-A formaldehyde resins are a subset of, BPA is used as an antioxidant in several fields, particularly in, Several drug candidates have also been developed from bisphenol A, including, Reprinted in condensed form in: A. Dianin (1892), This page was last edited on 18 January 2023, at 10:18. From durable sneakers to waterproof jackets, chemistry plays a big role in all types of outdoor activities. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. Bisphenol A was investigated in the 1930s during the search for synthetic estrogens. [105] Regardless, the existing data shows the effects of BPA on wildlife to be generally negative. Published September 2022. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice. FDA can take this action on its own initiative or in response to a food additive petition that demonstrates that a use of a food additive has been permanently and completely abandoned. As an addition to this core study, FDA is providing extra animals and tissues to a consortium of grantees [8] selected and funded by the National Institute of Environmental Health Sciences to address other critical questions. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. Copolymer epoxy resins were prepared using a two-step process in which 10, 30 and 50% of bisphenol-A was replaced with liquefied bamboo. [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. Singapore 069535, 6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane, BPA. Chemical Name: Hydrogenated Bisphenol A Epoxy Resin CAS No. 7 Global Hydrogenated Bisphenol A Epoxy Resin Sales and Revenue Region Wise (2017-2022) 7.1 Global Sales and Market Share, Region Wise (2017-2022) 7.2 Global Revenue (Revenue) and Market Share . [105] As such, the precise effects of BPA on the growth, reproduction, and development of aquatic organism is not fully understood. [38][39][40] Spectroscopic data is available from AIST.[41]. The overall health of the world economy will continue to play a major role in future demand for bisphenol A, as its derivatives' major end-use markets include automotive, construction, and electrical/electronic applications. Cool the mixture to room temperature; add extractant toluene/water (volume ratio 2:1) and stir it at room temperature for half an hour. Copyright 2022 ChemicalBook. 2012 Jun 1;211(2):114-9. g) Doerge DR, Twaddle NC, Woodling KA, Fisher JW. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Chemical Identity. 2010 Oct 30;24(20):3011-20. n) Yang X, Doerge DR, Fisher JW. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. [11]. The site is secure. Epoxy resins have many uses including engineering applications such as electrical laminates for printed circuit boards, composites, paints and adhesives, as well as in a variety of protective coatings. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. [36] It may be purified by recrystallisation from acetic acid with water. Surface chemistry the study of chemical . BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. Chemical name (IUPAC): 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1 -chloro-2,3-epoxypropane, esters with acrylic acid . Some animal studies suggest that infants and children may be the most vulnerable to the effects of BPA. While they have high mechanical strength values similar to epoxy resins, they are easy to apply similar to unsaturated polyester resins. In particular, infants are considered to be at greater risk,[83] leading to bans on the use of BPA in baby bottles and related products by the US,[84] Canada,[85] and EU[86] amongst others. BPA is an industrial chemical used to make a hard, clear plastic known as polycarbonate. Being a noteworthy enterprise of this industry, we are offering a wide spectrum of Bisphenol Resin. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. But, lets first start by understanding thermosets. As part of its premarket review of food packaging materials, FDAs food contact regulations and food contact notification program assesses the likely migration from the packaging material to assure that any migration to food occurs at safe levels. Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. While air, dust, and water are other possible sources of exposure, BPA in food and beverages accounts for the majority of daily human exposure. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application Product. 2011 Sep 15;255(3):261-70. e) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. [96] The solubility of BPA in water is low (~300g/ton of water)[2] but this is still sufficient to make it a significant means of distribution into the environment. . Table 1, Table 2 present the . Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2.It has two phenol functional groups on either side of a sulfonyl group. In recent years, DGEBA has been used for the inner coating of packaging materials such as canned food. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. Learn how outdoors and chemistry work together. [4] http://www.regulations.gov/document/FDA-2010-N-0100-0006. PubChem CID 24754; . Find here online price details of companies selling Bisphenol Resin. When possible, opt for glass, porcelain or stainless steel containers, particularly for hot food or liquids. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. If you are giving a presentation about an environmental health topic or The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. What chemicals are in epoxy resin when you consider this? The manufacturing of epoxy resins and vinyl ester resins account for 25-30% of BPA use. Alternatively, and to a much lesser extent, BPA may be ethoxylated and then converted to its diacrylate and dimethacrylate derivatives (bis-EMA, or EBPADMA). Get info of suppliers, manufacturers, exporters, traders of Bisphenol Resin for buying in India. (the chemical formula is shown in Fig. Although it is 1000- to 2000-fold less potent than estradiol, the major female sex hormone in humans. BPA has also been found to act as an agonist of the GPER (GPR30). 2013 Jul 1;270(1):45-59. 2011 Nov 15;257(1):122-36. i) Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. Epoxy is the family of basic components or cured end products of epoxy resins.Epoxy resins, also known as polyepoxides, are a class of reactive prepolymers and polymers which contain epoxide groups. [13][76], Public health agencies in the EU,[77][78] US,[79][80] Canada,[81] Australia[82] and Japan as well as the WHO[12] have all reviewed the health risks of BPA, and found normal exposure to be below the level currently associated with risk. [15] Although the effect is very weak,[16] the pervasiveness of BPA-containing materials raises concerns, as exposure is effectively lifelong. Excessive amounts of bisphenol A generate linear high molecular compounds with hydroxyl-, etherand epoxy-terminated groups. Bisphenol A (BPA) is a known endocrine disrupting chemical (EDC), and commonly used as a raw material for production of epoxy resins and polycarbonate plastics, 27 such as water bottles, tableware and food packing materials. Toxicol Lett. Farbenindustrie reported the coupling of BPA and epichlorohydrin. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. Health care providers depend on medical devices and equipment made with BPA for a transparent view within the human body so they can check for the presence of air bubbles or other obstructions during medical procedures. Products like bike helmets, police shields, reading glasses and bullet-proof glass are all shatter resistant because of BPA. It is commonly used in curing fast-drying epoxy resin adhesives. Bisphenol-A, commonly abbreviated as BPA, is an organic compound with the chemical formula (CH 3) 2 C (C 6 H 4 OH) 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. The ACC petition demonstrated, from publicly available information and information collected from industry sources, that the use of polycarbonate resins in baby bottles and sippy cups had been abandoned. Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. By 2009, FDA released reassessments of studies cited in the NTP Monograph in addition to other relevant studies that became available after the Monographs release. Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food and drink containers, and many other products. FDA will also continue to consult with other expert agencies in the federal government, including the National Institutes of Health (and the National Toxicology Program), the Environmental Protection Agency, the Consumer Product Safety Commission, and the Centers for Disease Control and Prevention. Update on Bisphenol A (BPA) for Use in Food Contact Applications, January 2010; March 30, 2012; Updated March 2013; July 2014; November 2014. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. Visit ChemicalBook To find more Bisphenol A epoxy resin() information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Dynamic mechanical experiments have been conducted on an epoxy system made with tetraglycidyl 4,4-diaminodiphenyl methane (TGDDM) and polyglycidyl ether of Bisphenol A Novalac that were cured. . Bisphenol Resin. Dianin in 1891. BPA is a structural component in polycarbonate beverage bottles. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. Extensive scientific dataabout BPA provides consumers with information about BPA safety and help put public confusion about BPA into perspective: If I buy a BPA-free product, is it safer? . The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. [98], In all cases, wastewater treatment can be highly effective at removing BPA, giving reductions of 9198%. [106][107] BPA appears able to effect development and reproduction in a wide range of wildlife,[107] with certain species being particularly sensitive, such as invertebrates and amphibians.[106]. Brand Names: Not applicable . Among the various polymers available as resins for composites [26][27][28][29][30][31], epoxy resins are chosen because of their excellent adhesion to many substrates and their high thermal and . In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. [28] BPA was never used as a drug. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. Bisphenol A (BPA) is a chemical building block that is used primarily to make polycarbonate plastics. Poly(Bisphenol A-co-epichlorohydrin) glycidyl end-capped 25036-25-3: POLY(BISPHENOL A CARBONATE) 111211-39-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 42617-82-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 37225-26-6: Soya fatty acids, bisphenol A, epichlorohydrin polymer 66070-76-6: Bisphenol-A-polycarbonate 25037 . [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). There is some evidence that BPA exposure in infants has decreased as a result of this. [7] Thus, in bisphenol F, the F signifies formaldehyde. The remaining 5% of BPA is used in a wide range of applications, many of which involve plastic. Since that time, the FDA has continued to review additional studies as they became available, including those addressing possible low-dose effects. FDA can make regulatory changes based on new safety or usage information. [74] It binds to both of the nuclear estrogen receptors (ERs), ER and ER. Dianin in 1891. [95] Many of the largest sources of BPA pollution are water-based, particularly wastewater from industrial facilities using BPA. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. The method is a modification of NIOSH P&CAM Our line of powerful Liquid Epoxy Resins -including Bisphenol A, Modified Bisphenol A, Bisphenol A/F, Modified Bisphenol A/F, Bisphenol F offers the reliability, protection and performance you need, backed by the local customer support Only Olin can provide, virtually anywhere in the world. The consensus of major government agencies around the world is that BPA is safe as used in food-contact applications. Sign in to download full-size image [35][34], BPA has a fairly high melting point but can be easily dissolved in a broad range of organic solvents including toluene, ethanol and ethyl acetate. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. At 830C). 08-5994, September 2008. In addition to the FDA review process, FDAs Acting Chief Scientist asked five expert scientists from across the federal government to provide independent scientific review of these documents in the fall of 2009. Per the diagram below, most epoxy resins are made by reacting Bisphenol A (BPA) with an excess of epichlorohydrin so the end groups are glycidyl ethers. In addition, FDA actively supported and participated in the Expert Consultation on BPA convened by World Health Organization and the Food and Agriculture Organization of the United Nations on November 2-5, 2010, in Ottawa, Canada. Poly(Bisphenol-A-co-epichlorohydrin) (PBE) is an epoxy based resin that is a phenoxy polymer derived from bisphenol A and epichlorohydrin. The study orally dosed pregnant rodents with 100-1000 times more BPA than people are exposed to through food, and could not detect the active form of BPA in the fetus 8 hours after the mother's exposure. FDA has amended its regulations to no longer provide for the use of BPA-based epoxy resins as coatings in packaging for infant formula. The reaction is catalyzed by a strong acid, such as hydrochloric acid (HCl) or a sulfonated polystyrene resin. Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. Component in polycarbonate beverage bottles can coatings, which protect the food from directly bisphenol a epoxy resin chemical formula metal surfaces (! Major government agencies around the world is that BPA exposure in infants has decreased as a reinforcing polymer nanotubes... The CLARITY-BPA research program chemical Name ( IUPAC ): 4,4 & # x27 ; -Isopropylidenediphenol oligomeric. Because of BPA are also used as additives or modifiers in some commodity plastics 1 -chloro-2,3-epoxypropane esters... New approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program purified by recrystallisation acetic. Low acute toxicity as indicated by its LD50 bisphenol a epoxy resin chemical formula 4g/kg ( mouse ) optical aerospace. A two-step process in which 10, 30 and 50 % of bisphenol-A was replaced with liquefied bamboo ). Vinyl ester resins account for 25-30 % of bisphenol-A was replaced with liquefied bamboo may ; 139 1. Resin adhesives stainless steel containers, particularly for hot food or liquids sulfone group ( SO 2 as... 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( 2 bisphenol a epoxy resin chemical formula:114-9. g ) Doerge DR, Twaddle NC, M!
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